3-FEA, systematic name: 1-(3-fluоrорhеnуl)-2-еthуlаmіnорrораnе. Belongs to the psychoactive classes Stimulants & Empathogens, and the chemical class Amphetamine. Early reports have so far characterized 3-FEA аѕ a mоdеrаtеlу potent ѕеrоtоnіn-dоmіnаnt substance. Produces a unique balance between еmраthоgеnіс and stimulant effects. There is limited information regarding toxicity. The mechanisms оf action аrе not fully understood.
However, 3-Fluoroethamphetamine (3-FEA) is known as a stimulant drug of the amphetamine class which acts as a releasing agent of the monoamine neurotransmitters norepinephrine, dopamine and serotonin. Compared to the un-substituted ethylamphetamine, 3-fluoroethamphetamine is a weaker releaser of noradrenaline, but a stronger releaser of both dopamine and serotonin, and produced the strongest reinforcing effects in animal studies out of a range of 3-substituted ethamphetamine derivatives tested, despite not being the most potent dopamine releaser.
Thus, just like its root compound 3-FA, the toxicological, pharmacological and the effects of 3-FEA in humans have yet to be documented. It is also reported that Anecdotal have characterised 3-FEA as a moderately potent serotonin-dominant triple monoamine releaser which produces a mixture of entactogenic and mild stimulating effects. Hence, due to its serotonin-releasing entactogenic properties, it is possible 3-FEA may display significant affinity and activity at the 5-HT2B receptor, which like 5-HT2B agonists such as MDMA and fenfluramine would make it cardiotoxic with long-term or heavy use. However, it is strongly recommended that one user should use proper harm reduction practices when using this substance 3-FEA
The history of 3-FEA in human recreational use is minimal and has not been documented being sold on the local market. Although as a research chemical by online vendors 3-FEA has recently been made available for sale on the grey market. As a result of its potent psychostimulant effects, likely habit-forming properties, and unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if using this 3-FEA.
3-FEA, or 3-fluoroethamphetamine, is a synthetic molecule of the amphetamine chemical class. Molecules of the amphetamine class contain a phenethylamine core comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain substituted with a methyl group at Rα (i.e. amphetamines are alpha-methylated phenethylamines).
3-FEA is the 3-position fluorinated analogue of ethylamphetamine (also known as ethamphetamine). It is also an analogue of fenfluramine with the 3-trifluoromethyl group replaced with a 3-fluoro substituent.
3-FEA has not been formally examining just like traditional amphetamines. Currently, it is assumed that like other substituted amphetamines with substitutions at similar positions, it most likely acts primarily as a triple reuptake inhibitor and releaser of the monoamine neurotransmitters serotonin, dopamine, and norepinephrine.
Thus, it is being indicated that 3-FEA effectively increases the levels of all the three major monoamine neurotransmitters dopamine, norepinephrine, and serotonin in the brain by acting as a releasing agent of ѕаіd nеurоtrаnѕmіttеrѕ and by binding to and partially blocking the transporter proteins that normally clear those molecules from the synaptic cleft after they have fulfilled their function of conducting a neural impulse. This transporter blockade triggers these molecules to accumulate within core synaptic regions of the brain to extra-endogenous levels, resulting in a combination of stimulating, disinhibiting, relaxing, and euphoric effects associated with entactogenic substituted MDMA or 4-FA.
Conclusively, the toxicity and long-term health effects of 3-FEA use haven’t been studied in any scientific context, so the exact toxic dosage is unknown. This is because 3-FEA has an extremely brief history of human usage, first becoming available in mid-2016. Early anecdotal reports from people within the community who have tried 3-FEA suggest that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it very cautiously sparingly (although nothing can be completely guaranteed.