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Ethyl-pentedrone (also known as n-ethyl-pentedrone and NEP) is a stimulant research chemical belonging to the cathinone class. Ethyl-pentedrone's stimulation is believed to be caused by its affinity as an NDRI (norepinephrine-dopamine reuptake inhibitor); however, there have been no scientific studies confirming this. It may also act as a serotonin reuptake inhibitor or releasing agent in moderate to high doses, but this is only speculation.
Ethyl-pentedrone is closely related to pentedrone, with an added ethyl-group on the carbon chain containing the nitrogen. This addition makes it about 3x as potent as pentedrone. Ethyl-pentedrone is also closely related to ethyl-hexedrone, and is likely very similar in effects.
Ethyl-pentedrone first became known in the research chemical market during 2016. Little research exists about ethyl-pentedrone and its parent compound pentedrone. All dosage information found on the internet should be treated with caution.
Ethyl-pentedrone is a cathinone, which means that it features a phenethylamine core with an alkyl group attached to the alpha carbon and an oxygen group attached to the beta carbon. Cathinones are beta-ketone analogues of amphetamines.
Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structure and subjective effect similarities to other cathinones such as mephedrone and others. Ethyl-Pentedrone most likely acts as both a dopamine and norepinephrine releasing agent or reuptake inhibitor. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects. It is possible that it may have some serotonergic properties, as users have described some entactogenic feelings.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.